儿童药物制剂产业化关键技术

姜栋, 宋辉, 靳雯臻, 郑稳生

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (21) : 1739-1745.

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中国药学杂志 ›› 2019, Vol. 54 ›› Issue (21) : 1739-1745. DOI: 10.11669/cpj.2019.21.003
药物制剂产业化新技术专栏

儿童药物制剂产业化关键技术

  • 姜栋, 宋辉, 靳雯臻, 郑稳生*
作者信息 +

The Key Technologies in Industrialization of Pediatric Preparations

  • JIANG Dong, SONG Hui, JIN Wen-zhen, ZHENG Wen-sheng*
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文章历史 +

摘要

中国0~14岁儿童占总人口约17%,用药规模超600亿,但儿童服药过程吞服困难、对味道敏感,再加上胃肠及肝肾功能尚未发育完全、免疫功能脆弱,对药物及剂型、剂量、口感、外观等均有特殊需求,但国内相应的儿童制剂缺乏,发展水平相较于欧美有显著差距,故对于限制我国儿童制剂发展的关键技术,如掩味技术,增溶技术,定量给药装置,儿童制剂用辅料,生产设备进行综述,以促进中国儿童药物制剂产业化关键技术的突破。

Abstract

The children aged 0-14 account for about 17% of the total population of China, medicines used by which cost more than 60 billion yuan per year. However, it is difficult for children to swallow medicines and children are more sensitive to taste. In addition, the gastrointestinal, liver and kidney functions are not yet fully developed and the immune function is weak. There are special needs for active pharmaceutical ingredient, dosage form, taste and appearance. However, there is a significant gap between China and Europe and America on pediatric preparations. To promote the breakthrough of key as taste-masking technologies, solubilizing technologies, quantitative dosing devices, technologies in industrialization of pediatric preparations in China, the key technologies, such pediatric excipients and production equipment, are reviewed.

关键词

儿童制剂 / 掩味 / 增溶 / 定量给药装置 / 辅料 / 生产设备

Key words

pediatric preparation / taste-masking / solubilizing / quantitative dosing device / excipient / production equipment

引用本文

导出引用
姜栋, 宋辉, 靳雯臻, 郑稳生. 儿童药物制剂产业化关键技术[J]. 中国药学杂志, 2019, 54(21): 1739-1745 https://doi.org/10.11669/cpj.2019.21.003
JIANG Dong, SONG Hui, JIN Wen-zhen, ZHENG Wen-sheng. The Key Technologies in Industrialization of Pediatric Preparations[J]. Chinese Pharmaceutical Journal, 2019, 54(21): 1739-1745 https://doi.org/10.11669/cpj.2019.21.003
中图分类号: R944   

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基金

十三五国家“重大新药创制”科技重大专项资助(2018ZX09721003-009-003,2018ZX09721003-007-007)
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